Use of Chelators to Decrease Lewy Body Aggregation in Parkinson’s Disease

For an introduction to Parkinson’s Disease (PD) and the role of metals, see “Atox1-Cu-𝛼Syn Complex Providing Answers about Possible Mechanisms of Aggregation of Lewy Bodies in Parkinson’s Disease” Researchers at Huazhong University of Science and Technology wanted to see if treating C. Elegans with chelating agents would decrease the overproduction and aggregation of 𝛼Syn. Knowing … Read more

Atox1-Cu-𝛼Syn Complex Providing Answers about Possible Mechanisms of Aggregation of Lewy Bodies in Parkinson’s Disease

Parkinson’s Disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease, affecting about 1-2 people 1000, including about 1% of people over 60. There are genetic markers in 5-10% of patients, but there is no direct connection as many patients develop symptoms without these markers. Symptoms of PD include difficulty walking and talking, … Read more

Metal Complexes Decrease Amyloid-ꞵ Formation and Increase the Concentration of Intracellular Copper and Zinc

Alzheimer’s disease (AD) is the most common neurodegenerative disease, affecting 5.8 million people in the United States, including about ½ of nursing home and hospice patients. AD causes cognitive decline, resulting in extreme memory loss, often to the point where patients may not be able to recognize their own children or spouse. Most patients are … Read more