Metals

The Importance of Metals in Viral Infections: The Influenza Virus RNA-Dependent RNA-Polymerase

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The COVID-19 pandemic has undoubtedly had a profound impact on the world. Its prevalence has been a daily talking point ever since the virus was declared a pandemic in March of 2020 by the World Health Organization. Through discussion around the origins and mechanisms of the disease, the public was exposed to and educated on … Read more

Using CRISPR/Cas9 to correct a Wilson’s Disease Mutation in Human Cells

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Wilson’s Disease (WD) is a liver disease caused by mutations in a protein responsible for copper excretion. That protein, ATPase7B (ATP7B), is a pump that helps move copper in liver cells, and mutations in it cause it to lose its ability to function. The impaired excretion of copper from the liver leads to the accumulation … Read more

ALS and pro-oxidant activity of a SOD-1 mutant

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ALS is a disease characterized by death of motor neurons and loss of motor function. There are two types of ALS; familial and sporadic, with sporadic ALS accounting for 90-95% of ALS cases. The familial form is associated with a heritable mutation in a number of genes such as superoxide dismutase 1, c9orf72, and many … Read more