mgaita

This research article studies the effects of deletion of Slc39a14 (zip14), a known manganese importer into the enterocytes and hepatocytes(Fig. 1), has on manganese homeostasis in the body. This study researches whole body zip14 knockout and intestine localized knockout of zip14 in mice. They then tested how manganese levels in the mice were affected and … Read more

Manganese is an essential nutrient attained through diet. While manganese is a necessary nutrient, it is toxic in excess. An excess of Manganese can result in a neurodegenerative disease called manganism. Manganism is generally the result of excessive manganese inhalation, mostly in work environments. However, in 2012 an inherited case of Slc30a10 mutation was identified … Read more