Importance of Copper in ALS and and Huntington’s Disease
Copper is an important cofactor for the functioning of various cuproenzymes that are required for proper brain development and functioning. For example, in superoxide dismutase-1 (SOD1), the binding of copper is necessary to break superoxide radicals that exhibit neurotoxicity. Many cuproenzymes have chaperones, such as copper chaperone for SOD1 (CCS), to facilitate binding of the … Read more