Metals, Metalloproteins and Disease
Wesleyan Blog
ALS is a disease characterized by death of motor neurons and loss of motor function. There are two types of ALS; familial and sporadic, with sporadic ALS accounting for 90-95% of ALS cases. The familial form is associated with a heritable mutation in a number of genes such as superoxide dismutase 1, c9orf72, and many … Read more
Menkes disease (MD) is caused by an X-linked inherited genetic mutation of the Cu-ATPase ATP7A. Since, it is an X-linked disorder, predominantly affects to the male population. It is the fatal disease for the children which can cause lethality within first 3 years of life. The hallmarks of MD are unusual sparse kinky hair on the … Read more
Is always great to listen to Svetlana’s great science!
I had the honor to train Courtney McCann when I was a PDoc and she was an undergrad at WPI 10 years ago… Take a look!
Copper (Cu) is a redox-active micronutrient that plays an important role in many physiological processes, as a cofactor for several enzymes involved in energy production, antioxidant processes, and homeostasis of other metals. We acquire Cu from our daily diet and Cu absorption occurs in the gastrointestinal lining of the small intestine. In our body, Cu … Read more
Welcome to our metals page! Transition metals (copper, zinc, manganese, cobalt, and many others) play many critical roles in all living organisms as they are essential constituents in a large number of biological processes. Metal control in cells requires several metal-binding molecules, transporters and sensors to prevent toxic reactions, but also to allow these elements … Read more
