Structural and biochemical analysis of the metallo-β-lactamase L1 from emerging pathogen Stenotrophomonas maltophilia revealed the subtle but distinct di-metal scaffold for catalytic activity
The emergence of antibiotic resistance is a major challenge in the clinical setting. Stenotrophomonas maltophilia is an emerging gram-negative bacterium that produces Metallo-b-lactamase (MBL) L1. Metallo-beta-Lactamases (MBLs) is a class B β-lactamases that hydrolyze β-lactam antibiotics. The β-lactam antibiotics, which include antibiotics such as penicillin, inhibit bacterial transpeptidases involved in cell-wall biosynthesis. Bacteria produce MBLs … Read more