dbonillapint

In this article, they are trying to find compound derivatives that can inhibit matrix metalloproteases by binding to the active site, effectively blocking them from performing their function. They characterized the inhibiting behavior of TPA, one of the most effective inhibitors, and found that upon diluting the enzyme off its inhibitor, that binding is reversible. … Read more

In this article, they wanted to see how MMP-14 was correlated with resistance to genotoxic stress and response of cancer to radio- and chemotherapy in patients. They demonstrate the elevated levels of expression of MMP-14, a matrix remodeling enzyme that degrades the extracellular environment for tissue invasion, in aggressive carcinomas compared to nonmetastatic ones, as … Read more

This article seeks to understand the relationship between the transcription factor Ets-1 and cancer progression. To do this, they test whether Ets-1 activation leads to the expression of MMP-9, a matrix remodeling protein that degrades extracellular components to facilitate tissue invasion in carcinoma. They found this to be the case when reducing expression of Ets-1 … Read more

This review explores how epithelial-mesenchymal transition (EMT), an important process of cancer progression and metastasis, is regulated by a group of transcription factors. Some of the worst types of breast cancers present high levels of ZEB1/2, a family of transcription factors that are associated with EMT. In cells with high levels of ZEB1/2, ERK pathways … Read more